Показатели анализа крови при метастазах в кости

Показатели анализа крови при метастазах в кости

, ,

Diel and Solomayer (1996) : (50-90%), (10-40%), (<10%), (10-20%) (<10%). . . , . , , , ( ., 2001). , , , , , , .

, — ; , .

, , , . . . . . , , . — 20 , 2494 , 2% 48% 35% (Funke and Schraut, 1998). , , IV . Reichman Osborne (1998) 38% IV , 20% 10% .

, , , . Kirk et al. (1990) : 4 25 9 13 . Coombs . (1983) , I, II, III . Braun et al. (2000) Wiedswang et al. (2001) , , (P<0,001), (=0,77); (=0,13). Berger et al. (1988), Dearnaley et al. (1991), Mansi et al. (1991), Diel et al. (1996) (P<.05) /. , Berger et al. (1988) Mansi et al. (1991) , , , . (Kirk et al., 1990; Salvadori et al., 1990; Cote et al., 1991; Dearnaley et al., 1991; Singletary et al., 1991; Diel et al., 1996; Molino et al., 1997). . Harbeck et al. (1994), Diel et al. (1996), Braun et al. (2000) Wiedswang et al. (2003) , .

, , , , (MEDLINE, CANCERLIT), , . , .

.

. 14 , 1999 2003 . . — . -, — , . , — .

40-49 (n=5) 50-59 (n=8). : IIa 4 , IIb — 8, IV 2 . , 4 1 , 2 1 3 , 7 , 3 .

.

. 2 , 4 , 6 , 2 . , , . , , , . (n=9) : , , 37,5-38. : 7 IIIII , 11 ( 50 /); (4 ) (2 ). .

, , , . (, CAF, FAC, DA), . 5 . -89. , , , IV ., 1 . 7 , . , 2-4 , — . . , -89, .

, 5,5 . 16,6 .

.

, . , , — . (, ).

:

1. , , . . // .-2002.-3.-.15-20.

2. , , .- .: 2001.-256 .

3. Berger U., Bettelheim R., Mansi J. L. et al. The relationship between micrometastases in bone marrow, histopathologic features of the primary tumor in breast cancer and prognosis // Am. J. Clin. Pathol.-1988.-Vol. 90.-P.1-6.

4. Braun S., Kentenich C., Janni W. et parative Analysis of Micrometastasis to the Bone Marrow and Lymph Nodes of Node-Negative Breast Cancer Patients Receiving No Adjuvant Therapy // J. Clin. Oncol.-2000.-Vol. 18.-P.80-86

5. Coombs R. S., Redding W. H., Sloane J. P. et al. Detection of micrometastases in breast cancer // Proc. Asco.-1984.-Vol. 3.-P.116

6. Cote R. J., Rosen P. P., Lesser M. et al. Prediction of early relapse in patients with operable breast cancer by detection of occult bone marrow micrometastases // J. Clin. Oncol.-1991.-Vol. 9.-P..

7. Dearnaley D. P., Sloane J. P., Omerod M. G. et al. Increased detection of mammary carcinoma cells in marrow smears // J. Roy Soc. Med.-1983.-Vol. 76.-P.359-364.

8. Dearnaley D. P., Omerod M. G., Sloane J. P. et al. Micrometastases in breast cancer: Long-term follow-up of the first patient cohort // Eur. J. Cancer.-1991.-Vol. 27.-P236-239.

9. Diel I. J., Solomayer E. F. Bisphosphonates in the antiosteolytic therapy of metastatic breast cancer // Zentralbl. Gynakol.-1996.-Vol. 118.-P.1-5.

10. Diel I. J., Kaufman M., Costa S. D. et al. Micrometastatic breast cancer cells in bone marrow at primary surgery: Prognostic value in comparison with nodal status // J. Natl. Cancer Inst.-1996.-Vol. 88.-P..

11. Funke I., Schraut W. Meta-Analyses of Studies on Bone Marrow Micrometastases: An Independent Prognostic Impact Remains to Be Substantiated // J. Clin. Oncol.-1998.-Vol. 16.- P.557-566.

12. Harbeck N., Untch M., Pache L. Tumor cell detection in bone marrow of breast cancer patients at primary therapy: Results of a 3-year median follow-up // Br. J. Cancer.-1994.-Vol.69.-P.566-571.

13. Kirk S. J., Cooper G. G., Hoper M. et al. The prognostic significance of marrow micrometastases in women with early breast cancer // Eur. J. Surg. Oncol.-1990.-Vol. 16.-P.481-485.

14. Mansi J. L., Easton D., Berger U. et al. Bone marrow micrometastases in primary breast cancer: Prognostic significance after 6 years follow-up // Eur. J. Cancer.-1991.-Vol. 27.-P.236-239.

15. Molino A., Pelosi G., Turazza M. et al. Bone marrow micrometastases in 109 breast cancer patients: Correlations with clinical and pathological features and prognosis // Breast Cancer Res. Treat.-1997.-Vol. 42.-P.23-30.

16. Reichman B. S., Osborne M. P. // The Breast: Comprehensive Management of Benign and Malignant Diseases.-Philadelphia, 1998.-Section XXI, ch. 70.-P..

17. Salvadori B., Squicciarini P., Rovini D. et al. Use of monoclonal antibody MBr1 to detect micrometastases in bone marrow specimens of breast cancer patients // Eur. J. Cancer.-1990.-Vol. 26.-P.865-867.

18. Singletary S. E., Larry L., Tucker S. et al. Detection of micrometastatic tumor cells in bone marrow of breast carcinoma patients // J. Surg. Oncol.-1991.-Vol. 47.-P.32-36.

19. Wiedswang G., Borgen E., Karesen R. et al. Detection of isolated tumor cells in bone marrow is an independent prognostic factor in breast cancer // J. Clin. Oncol.-2003.-Vol. 15.-P. 3

. 2004. 3. . 5-7



Источник: pandia.ru


Добавить комментарий